Smudge cells
Smudge cells
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Short-Answer Questions on Smudge Cells
- What type of leukemia is most commonly associated with smudge cells?
Answer: Chronic Lymphocytic Leukemia (CLL) - What causes the formation of smudge cells on a peripheral blood smear?
Answer: Mechanical disruption of fragile lymphocytes during slide preparation - What is another term used to describe smudge cells?
Answer: Basket cells - Which staining technique is commonly used to identify smudge cells?
Answer: Wright stain - What laboratory method can help reduce the number of smudge cells on a smear?
Answer: Adding albumin to the blood sample before smear preparation - What component of the cell is typically lost in smudge cells due to their fragility?
Answer: Cytoplasmic membrane - In which age group are smudge cells most frequently observed?
Answer: Elderly adults - What does the presence of smudge cells suggest in a clinical context?
Answer: Possible diagnosis of Chronic Lymphocytic Leukemia - Why does a high lymphocyte count contribute to more smudge cells?
Answer: Increased fragility and mechanical damage of excess lymphocytes - What protein, when added to a smear slide, stabilizes lymphocytes and reduces smudge cells?
Answer: Albumin
