Medicine MCQs -6 : Folates
Folate is also known as -
Folate- vitamin B9 https://medicalwikipedia.org/
Vitamin B1
Thiamine
Required as coenzyme in the catabolism of sugars and amino acids.
Vitamin B2
Riboflavin
A precursor of coenzymes called FAD and FMN, which are required for flavoprotein enzyme reactions. Vitamin B3
Niacin (nicotinic acid)
A precursor of coenzymes called NAD and NADP required for metabolic processes.
Nicotinamide
Nicotinamide riboside
Vitamin B5
Pantothenic acid
A precursor of coenzyme A
metabolize many molecules.
Vitamin B6
Pyridoxine
Required as coenzyme in metabolism.
Pyridoxal
Pyridoxamine
Vitamin B7
Biotin
Coenzyme for carboxylase enzymes
Required for of fatty acids and in gluconeogenesis.
Vitamin B9
Folate
Required for repair, and methylate DNA;
Cofactor in various reactions involving rapid cell division and growth, such as in infancy and pregnancy.
Vitamin B12
Cobalamins
Coenzyme involved DNA synthesis and regulation,fatty acid metabolism and amino acid metabolism.
Deficiency of iron may be masked by which vitamin deficiency?
Deficiency of folic acid or vitamin B12 may mask the deficiency of iron
Which is the most frequently affected tissues in folate and vitamin - B12 deficiency?
Marrow - most commonly affected tissue in folate and vitamin - B12 deficiency
Next most frequently affected tissues are -
Mouth,
Stomach,
Small intestine
Respiratory,
Urinary,
Female genital tracts.
Which of the following mediates uptake of methotrexate by cells?
Reduced folate transporter -mediates uptake of methotrexate by cells.
Which vitamin deficiency causes 'methylfolate trap' ?
Vitamin -B12 -
THF starvation or the methylfolate trap:
MTHF accumulates in plasma
Intracellular folate concentrations fall due to failure of formation of THF
Risk of neural tube defects is associated with deficiency of -
Folic acid is- supplement by women during pregnancy to reduce the risk of neural tube defects
All of the following enzyme deficiency cause homocystinuria EXCEPT ?
Deficiency of enzymes that cause homocystinuria -
- Methionine synthase
- MTHFR
- Cystathionine synthase
Folates are best absorbed from -
Folates are best absorbed from the upper small intestine
Large amounts of supplemental folic acid can hide ------------- deficiency
Large amounts of supplemental folic acid can hide vitamin B12 deficiency
Elevated Methyl malonic acid levels indicate ---------- deficiency
Please select 2 correct answers
vitamin B12
Gastric cells
Gastric cells Cells found in the gastric glands include CellsAlso calledSecret1Foveolar cellsMucous neck cells Mucus2Chief…
Megaloblastic Anemia MCQs
Transcobalamin-1 [Haptocorrin] is derived primarily from -
Transcobalamin-1 [Haptocorrin] is derived primarily from the specific granules in neutrophils.
Cobalamin requires Intrinsic Factor for absorption in ------------ cases
Cobalamin requires IF for absorption - 99%. Free cobalamin is absorbed passively in the terminal ileum -1%. This why oral replacement with large vitamin is required in pernicious anemia
Which of the following helps in protection of the acid-sensitive vitamin B12 while it moves through the stomach?
Essential function of haptocorrin is protection of the acid-sensitive vitamin B12 while it moves through the stomach
Which of the following is major natural cobalamin?
Forms of cobalamin -
• Adenosylcobalamin • Cyanocobalamin • Hydroxocobalamin • Methylcobalamin
Which of the following has a cobalt atom at the center of a corrin ring?
Vitamin B12 - has a cobalt atom at the center of a corrin ring.
Methylmalonyl coenzyme A mutase uses -------------- to convert L-methylmalonyl-CoA to succinyl-CoA, an important step in the catabolic breakdown of some amino acids into succinyl-CoA.
Methylmalonyl coenzyme A mutase (MUT) is an isomerase enzyme which uses the Adenosylcobalamin form to convert L-methylmalonyl-CoA to succinyl-CoA, an important step in the catabolic breakdown of some amino acids into succinyl-CoA, which then enters energy production via the citric acid cycle.
Methylmalonyl-CoA mutase (MCM) [mitochondrial] also known as methylmalonyl-CoA isomerase
Methylmalonyl-CoA mutase is a vitamin B12-dependent enzyme that catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA in humans. This functionality is lost in vitamin B12 deficiency, and can be measured clinically as an increased serum methylmalonic acid (MMA) concentration.
Cobalamin is synthesized by -
Cobalamin is synthesized solely by microorganisms.
Cubilin receptors are present in -
Cubilin receptors are present in -
- Ileum - helps to absorb Vitamin B12 - IF Complex
- Yolk sac
- Renal proximal tubular epithelium
Bioactive forms of vitamin B12 in mitochondria?
Bioactive forms of vitamin B12 -
• Methylcobalamin in cytosol
• Adenosylcobalamin in mitochondria
Intrinsic Factor for Vitamin -B12 is produced by which cells?
IF is produced in the gastric parietal cells of the fundus and body of the stomach, and its secretion parallels that of hydrochloric acid.
Gastric cells -
Cells found in the gastric glands include -
-Foveolar cells - also called mucous neck cells - produce mucus
-Chief cells - Zymogen cells/ peptic cells - zymogens – pepsinogen (precursor to pepsin) and prorennin [in childhood only ]
-Parietal cells - oxyntic cells -secrets : HCl , castle's intrinsic factor
-G cells - secret : gastrin hormone
-D-cells - secret : somatostatin
-Enterochromaffin- like cells (ECLs) - release serotonin and histamine
Haptocorrin
Follow the link to Get Answers Contents What are the other names of Haptocorrin?What is…
What are the types of homocystinuria?
What are the types of homocystinuria? Homocystinuria type-I- Due to the deficiency of cystathionine ß…
Medicine MCQs-4
Microcytosis is reflected by MCV -
Microcytosis - MCV < 80
Macrocytosis. - MCV >100
All of the following are classified as myloproliferative neoplasms EXCEPT -
World Health Organization lists the following subcategories of MPNs:
• Chronic myeloid leukemia
• Chronic neutrophilic leukemia
• Polycythemia vera
• Primary myelofibrosis
• PMF, Prefibrotic Stage
• PMF, Overt Fibrotic Stage
• Essential thrombocythemia
• Chronic eosinophilic leukemia
Previously, myloproliferative neoplasms were known as myeloproliferative diseases
Philadelphia Chromosome is seen in -
Chronic myeloid leukemia (CML) has a presence of the hallmark Philadelphia Chromosome (BCR-ABL1) mutation.
Presence of splenomegaly in a patient with polycythemia supports a diagnosis of -
Presence of splenomegaly supports a diagnosis of polycythemia vera rather than secondary polycythemia.
Castell's sign is a medical sign assessed to evaluate -
Castell's sign is a medical sign assessed to evaluate splenomegaly
Signs of hypovolemic shock appears when acute blood loss is -
Volume of acute blood lost is >40% [ i.e.,>2L in the average-sized adult ] signs of hypo-volemic shock appears
Presence of a palpable spleen in a patient with sickle cell disease after age 5 suggests -
Presence of a palpable spleen in a patient with sickle cell disease after age 5 suggests a coexisting hemoglobinopathy, e.g., thalassemia or hemoglobin C
All of the following are associated with massive splenomegaly EXCEPT -
DISEASES ASSOCIATED WITH MASSIVE SPLENOMEGALY -
- Chronic myeloid leukemia
- Gaucher’s disease
- Lymphomas
- Chronic lymphocytic leukemia
- Hairy cell leukemia
- Sarcoidosis
- Polycythemia vera
Sickle cell anemia - autosplenectomy
Pneumococcal sepsis- has been reported to cause autosplenectomy but is a very rare
All of the following are adaptive functions of normal human Spleen EXCEPT -
Adaptive unctions of Spleen :
(1) Clearance of bacteria and particulates from the blood,
(2) Immune responses to pathogens,
(3) Extramedullary hematopoiesis
Normal human spleen does not sequester or store red blood cells and does not contract in response to sympathetic stimuli.
Gaisbock’s syndrome is best categorized under the heading of -
Gaisbock’s syndrome is best categorized under the heading of a relative polycythemia
Medicine MCQs – 3
How addition of hydroxychloroquine to doxycycline for treatment against C. burnetii helps?
Addition of hydroxychloroquine to doxycycline against C. burnetii helps to - alkalinize the phagolysosome
Hydroxychloroquine increases lysosomal pH in antigen-presenting cells by two mechanisms: As a weak base, it is a proton acceptor and via this chemical interaction, its accumulation in lysozymes raises the intralysosomal pH
Which is the most common bacterial cause of pneumonia?
Streptococcus pneumoniae is the most common bacterial cause of pneumonia
Which is called as 'walking pneumonia' ?
Walking pneumonia
"Primary atypical pneumonia" is called primary because it develops independently of other diseases.
Known as "walking pneumonia" because its symptoms are often mild enough that one can still work and walk.
What is the drug of choice of rocky mountain spotted fever in pregnant patients
Drug of choice for the treatment of both children and adults with rocky mountain spotted fever is doxycycline, except when the patient is pregnant
Pregnancy - Treatment with chloramphenicol, a less effective drug, is advised only for patients who are pregnant
C. burnetii escapes intracellular killing in macrophages by inhibition of -
C. burnetii
- gram-negative cell wall,
- survives in harsh environments
- escapes intracellular killing in macrophages by inhibiting the final step in phagosome maturation (cathepsin fusion)
- has adapted to the acidic phagolysosome by producing superoxide dismutase
All of the following are characteristic lab finding of rickettsioses EXCEPT -
Characteristic laboratory findings -
- Thrombocytopenia
- Normal or low white blood cell [WBC] counts, elevated hepatic enzyme levels
- Hyponatremia
Which is the most frequently detected “atypical” organism in community-acquired pneumonia in adults?
Community-acquired pneumonia in adults - M. pneumoniae is the most frequently detected “atypical” organism.
Which of the following is the most frequently reported travel-associated rickettsial infections?
Tickborne spotted fever rickettsioses are the most frequently reported travel-associated rickettsial infections.
Brill-Zinsser disease is a type of -
Brill–Zinsser disease :
- relapse of epidemic typhus, caused by Rickettsia prowazekii.
- Brill-Zinsser disease is an exacerbation of epidemic louse-borne typhus fever.
- Caused by Rickettsia prowazekii.
- Rather than being eradicated, the microorganisms become latent and reappear after several years as a milder form of the disease.
What is the causative agent of rickettsialpox?
causative agent of rickettsialpox - R. akari
Medicine MCQs – 2
Café au lait spots with rough borders seen in -
Café au lait spots are often harmless but may be associated with syndromes such as neurofibromatosis type 1 and McCune–Albright syndrome
Neurofibromatosis Type 1 -
- Café au lait lesions tend to resemble the "coast of California," rather than the "coast of Maine," - Meaning the edges are smoother and more linear.
McCune-Albright syndrome.- Café au lait lesions with rough borders (“coast of Maine”)
Low-FODMAP diet is used for -
Dietary modification to reduce the volume of flatus produced is - reducing the amount of fermentable carbohydrates.
Low-FODMAP diet- low fermentable oligosaccharide, disacharide, monosaccharide and polyols
Horizontal nystagmus is best assessed at -
Horizontal nystagmus is best assessed at 45° and not at extreme lateral gaze
Patients with aerophagia have excessive intestinal gas that is mostly composed of -
Patients who have excessive intestinal gas that is mostly composed of nitrogen have aerophagia
Check shoulder shrug or trapezius muscle action is the testing of which nerve -
CN XI (Spinal Accessory) Check shoulder shrug (trapezius muscle) and head rotation to each side (sternocleidomastoid) against resistance.
Most common form of electrolyte disorder in the emergency room
Hyponatremia is the most common form of electrolyte disorder in the emergency room
Most common form of glomerulonephritis in adults worldwide -
IgA nephropathy is also known as Berger's disease. It is the most common form of glomerulonephritis in adults worldwide
IgA nephropathy, also known as Berger's disease, is the most common type of glomerulonephritis, and generally presents with isolated visible or occult hematuria, occasionally combined with low grade proteinuria
Bilateral renal cell carcinomas is seen in -
von Hippel–Lindau disease -
- autosomal dominant disorder We can find - - bilateral renal cell carcinomas - haemangioblastomas - phaeochromocytomas - renal cysts
VHL syndrome is found in 4.3% of bilateral RCCs
Early-morning nausea and vomiting is seen in all of the following cases EXCEPT -
Early-morning nausea and vomiting is seen in -
- Pregnancy
- Alcohol dependence
- Uraemia.
Large volumes of vomit - suggest gastric outlet or upper intestinal obstruction.
All of the following are usually CORRECT about Isolated proteinuria without hematuria EXCEPT -
Isolated proteinuria without hematuria
is usually in the sub-nephrotic range without an active urine sediment and there is normal renal function. Over 50% of these patients have postural proteinuria.
Café au lait spots
Café au lait spots are often harmless but may be associated with syndromes such as…
Hypercalcemia
Hypercalcemia – when calcium concentration is >14 mg/dL, individuals may experience confusion, altered mental status, coma,…
Acetaminophen & Hepatic injury
Blood levels of acetaminophen correlate with severity of hepatic injury levels >300 μg/mL 4 h…
Medicine MCQs -1
Patient presented with clinical symptoms include bleeding problems and on examination found to have hepatosplenomegaly blood parameters shows thrombocytopenia, elevated bile acid with normal bilirubin, and mildly prolonged prothrombin time and elevated concentrations of ribitol, arabitol, and erythritol in urine sample. Which of the following is the possibility?
Transaldolase (TALDO) Deficiency
Clinical symptoms include-
Bleeding problems, hepatosplenomegaly, liver cirrhosis, thrombocytopenia, elevated bile acid with normal bilirubin, and mildly prolonged prothrombin time
The deficiency of TALDO enzyme is diagnosed by elevated concentrations of ribitol, arabitol, and erythritol in urine sample.
Jordans anomaly shows persistent vacuolation of -
Jordans anomaly [Jordans bodies]- persistent vacuolation of granulocytes and monocytes in the peripheral blood and bone marrow.
ordans' anomaly is a characteristic finding in Chanarin-Dorfman syndrome and other neutral lipid storage diseases.
Associated with mutations in the PNPLA2 gene
Which of the following is called as Vanishing white matter disease-
Vanishing white matter disease-
Childhood ataxia with central hypomyelination (CACH),
Genetic leukoencephalopathy due to mutations in EIF2B subunit mutations,
Extensive white matter involvement with cavitary changes.
Tay–Sachs disease becomes apparent almost always by which month of life?
Tay–Sachs disease - disease becomes apparent in the first weeks and months of life, almost always by the fourth month
PGL4 syndrome is caused by mutation of -
PGL4 syndrome - due to SDHB mutations
SDHB gene provides instructions for making one of four subunits of the succinate dehydrogenase (SDH) enzyme.
Tay–Sachs disease is caused by insufficient activity of the enzyme -
Tay–Sachs disease is caused by insufficient activity of the enzyme hexosaminidase A
Krabbe disease is caused by-
mutations in the
GALC gene located on chromosome 14
Autosomal recessive
Mutations in the GALC gene cause a deficiency of an enzyme called galactosylceramidase.
Mutations in the SMPD1 gene cause Niemann–Pick disease types A and B.
They produce a deficiency in the activity of the lysosomal enzyme acid sphingomyelinase which breaks down the lipid sphingomyelin
When both parents are carriers for Tay–Sachs disease there is how much % risk of giving birth to an affected child with each pregnancy?
Tay–Sachs disease is an autosomal recessive genetic disorder- when both parents are carriers, there is a 25% risk of giving birth to an affected child with each pregnancy
Sea-blue histiocytes are seen in all of the following EXCEPT-
Sea-blue histiocytes is a secondary finding associated with -
myelodysplastic syndromes,
lymphomas,
chronic myelogenous leukemia,
idiopathic thrombocytopenic purpura,
Niemann-Pick disease,
Norum disease
Sea-Blue histiocytosis
Synonyms
Inherited Lipemic Splenomegaly
Histiocytosis, sea-blue
Sea-Blue histiocyte disease
Cherry-red spot at macula is seen in all of the following cases EXCEPT -
Cherry-red spot at macula in Metabolic Storage Diseases:
Tay–Sachs disease
Farber disease
GM1 and GM2 gangliosidoses
Metachromatic leukodystrophy
Niemann–Pick disease
Sandhoff disease
Sialidosis
Tay–Sachs disease is caused by a genetic mutation in -
Hexosaminidase A (alpha polypeptide)[ HEXA] is an enzyme that in humans is encoded by the HEXA gene, located on the 15th chromosome.
Tay–Sachs disease is caused by a genetic mutation in the HEXA gene
Taxonomy
Heart Failure -I
What is the commonest cause of heart failure?
Ischaemic heart disease - 35–40%
Cardiomyopathy (dilated) - 30–34% Hypertension - 15–20%
Weight loss of 4.5 kg in ............ days in response to treatment is a Framingham major criteria.
The Framingham criteria for the diagnosis of heart failure consists of the concurrent presence of either two major criteria or one major and two minor criteria.
Major criteria comprise the following:
Paroxysmal nocturnal dyspnea
Weight loss of 4.5 kg in 5 days in response to treatment
Neck vein distention
Rales
Acute pulmonary edema
Hepatojugular reflux
S 3 gallop
Central venous pressure greater than 16 cm water
Circulation time of 25 seconds or longer
Radiographic cardiomegaly
Pulmonary edema, visceral congestion, or cardiomegaly at autopsy
Minor criteria (accepted only if they cannot be attributed to another medical condition) are as follows:
Nocturnal cough
Dyspnea on ordinary exertion
A decrease in vital capacity by one third the maximal value recorded
Pleural effusion
Tachycardia (rate of 120 bpm)
Hepatomegaly
Bilateral ankle edema
Licorice can worsen heart failure by -
Licorice can worsen heart failure by increasing blood pressure and promoting fluid retention.
Yohimbine can exacerbate heart failure by increasing blood pressure through -
Yohimbine can exacerbate heart failure by increasing blood pressure through alpha-2 adrenergic receptor antagonism
Which of the following stages of heart failure the patient belongs to when the patient has structural heart disorder, but no symptoms at any stage?
Stage A: People at high risk for developing HF in the future, but no functional or structural heart disorder Stage B: A structural heart disorder, but no symptoms at any stage Stage C: Previous or current symptoms of heart failure in the context of an underlying structural heart problem, but managed with medical treatment Stage D: Advanced disease requiring hospital-based support, a heart transplant, or palliative care
Heart failure cells are -
Heart failure cells are siderophages generated in the alveoli of the lungs of people with left heart failure or chronic pulmonary edema
Patients who achieve at least............. MET-minutes/week had lower heart failure
Recommended minimum by U.S. guidelines -
Patients who achieve at least 500 MET-minutes/week had lower heart failure
Which of the following should be used in those patients who still have symptoms while on an ACE-I or ARB, beta blocker, and a mineralocorticoid receptor antagonist?
Sacubitril/valsartan should be used in those who still have symptoms while on an ACE-I or ARB, beta blocker, and a mineralocorticoid receptor antagonist as it reduces the risks of cardiovascular mortality and hospitalization for heart failure by a further 4.7% (absolute risk reduction).
All of the following is used for risk Stratification in heart failure EXCEPT?
Framingham criteria for the diagnosis of heart failure
Tolvaptan antagonises which of the following receptor?
VAPTANS
Unselective (mixed V1A/V2)
Conivaptan
V1A selective (V1RA)
Relcovaptan
V1B selective (V3RA)
Nelivaptan
V2 selective (V2RA)
Lixivaptan
Mozavaptan
Satavaptan
Tolvaptan
Atrial fibrillation occurs in approximately ------------% of patients with heart failure.
Atrial fibrillation occurs in approximately 20% of patients with heart failure and causes further impairment of cardiac function
Medicine Review MCQs-XVI
Which of the following is Naturally occurring cysteine-rich antibacterial and antifungal polypeptides?
Defensins are naturally occurring cysteine-rich antibacterial and antifungal polypeptides
- 29–35 amino acids
Mast cells share features in common with which of the following cell?
Mast cells share features in common with - Basophils
- Histamine-containing granules
- High-affinity receptors for immunoglobulin E
All of the following are TRUE about Histamine EXCEPT -
Histamine - constitutes 10% of the mast cell’s weight
IgM is a useful diagnostic test for -
- IgM is a useful diagnostic test for recent infection.
- IgG dominates in the second exposure to antigen
CD4+ T cells also known as -
T helper cells-
- assist other lymphocytes, including maturation of B cells into plasma cells and memory B cells,
- activation of cytotoxic T cells and macrophages.
- These cells are also known as CD4+ T cells as they express the CD4 glycoprotein on their surfaces.
IgA2 concentration are higher in -
IgA exists in two isotypes, IgA1 and IgA2.
They are both heavily glycosylated proteins.
While IgA1 predominates in serum (~80%),
IgA2 percentages are higher in secretions than in serum (~35% in secretions)
Which of the following vasculitis caused by deposits of IgA?
Henoch–Schönlein purpura - Known as IgA vasculitis - is a disease of the skin, mucous membranes
All of the following are vasculitis where mostly small vessels are affected EXCEPT -
According to the size of the vessel affected, vasculitis can be classified into:
- Large vessel: Takayasu's arteritis, Temporal arteritis
- Medium vessel: Buerger's disease, Kawasaki disease, Polyarteritis nodosa
- Small vessel: Behçet's syndrome, Eosinophilic granulomatosis with polyangiitis, Cutaneous vasculitis, granulomatosis with polyangiitis, Henoch–Schönlein purpura, and microscopic polyangiitis.
Which is the most commonly implicated drug in causing Linear IgA bullous dermatosis?
Most commonly implicated drug - Vancomycin
All of the following are TRUE Light-chain multiple myeloma EXCEPT -
Light-chain multiple myeloma is a less frequent type of multiple myeloma with a more aggressive course and poorer prognosis.
It is characterized by the inability of the malignant plasma cells to produce heavy chains, resulting in the exclusive production of light chains. Therefore, no M-spike is visible in serum protein electrophoresis.
Exclusive production of light chains No M-spike is visible in serum protein electrophoresis.
