Brain abscess and empyema
Contents1 Which of the following heart conditions predispose to brain infection and abscess2 All are...
Clinical Questions -3
Contents1 Presentation2 MRI Scan Image3 What is your diagnosis?4 In shorts Presentation A 70-year-old Indian...
Image Question-33
Contents1 What is the Diagnosis of Image?2 What sign is seen in MRI Scan arrow...
Hydrocephalus
Contents1 The main site of CSF absorption are arachnoid granulations of2 All are true of...
Schaffer collaterals
Contents1 Schaffer collaterals are present in2 Which of the following has ‘Schaffer collaterals’?3 Schaffer collaterals...
Anticipatory emesis
Cortical pathway which is responsible for anticipatory emesis in chemotherapy-induced nausea and vomiting is mediated...
Chemotherapy induced vomiting
Acute onset of nausea and vomiting after administration of chemotherapy usually resolves A. < 24...
Radiation encephalopathy
Contents1 Early delayed radiation encephalopathy occurs —— after irradiation2 Acute radiation encephalopathy3 Early delayed radiation...
Raised intracranial pressure
Contents1 Parinaud’s syndrome in children results from2 Not true of physiology of CSF flow is3...
Clinical Questions -2
Contents1 Presentation2 Laboratory studies3 CT Scan Image4 What is your diagnosis? Presentation A 71-year-old woman...
Banding Techniques
Staining/banding. What is Banding Technique? Chromosome banding is an essential technique used in chromosome karyotyping…
Klinefelter syndrome
ALL of the following are clinical features of Klinefelter syndrome EXCEPT -A. weaker musclesB. short…
Hypoxic Cell Injury
What is the most common cause of cell injury?Hypoxia.Hypoxia is the most common cause of…
Motility Disorders – MCQs
Esophagus develops from the cranial portion of the foregut and is recognizable by -A. Second…
Chromosomal disorders -MCQs
Usual procedure to examine chromosomes is to arrest dividing cells in ———— ?A. ProphaseB. MetaphaseC….
Metaplasia – MCQs
Most common epithelial metaplasia is -A. Columnar to SquamousB. Squamous to Columnar C. Transitional to…
Edema – MCQs
Which of the following is characteristic finding in severe renal disease?A. Pedal edemaB. Sacral edemaC….
Vascular Function MCQs
Which of the following is CORRECT for a blood vessel as the vessels become smallerA….
Babesia
Maltese-cross form is a characteristic feature of which of the following parasite?A. Schistosoma mansoniB. Brugia malayiC….
Blast crisis
Blast crisis 1. Blast Crisis is Diagnoses when Blast count is -A. >10%B. > 20%C….
CRAB criteria
CRAB criteria is used for – A. Chronic Myeloid Leukemia B. Multiple Myeloma C.Renal Cell…
Medicine MCQs – 23
Which medicine dramatically alters the natural course of PNH, reducing symptoms and disease complications as well as improve survival?
Eculizumab- is a medication used to treat
- paroxysmal nocturnal hemoglobinuria (PNH)
- atypical hemolytic uremic syndrome (aHUS)
- generalized myasthenia gravis
- neuromyelitis optica
Eculizumab is a recombinant humanized monoclonal antibody against the complement protein -
Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5
Under normal circumstances, free hemoglobin released by hemolysis is removed by -
Clinical settings - Haptoglobin assay is used to screen for and monitor intravascular hemolytic anemia.
In intravascular hemolysis, free hemoglobin will be released into circulation and hence haptoglobin will bind the hemoglobin. This causes a decline in haptoglobin levels.
All of the following are correct for Paroxysmal nocturnal hemoglobinuria EXCEPT:
In PNH - Mutation of the X-linked gene phosphatidylinositol glycan class A (PIGA), produces a deficiency in the glycosylphosphatidylinositol (GPI) protein, which is responsible for anchoring other protein moieties to the surface of erythrocytes.
All of the following are CORRECT about thrombosis in PNH patients EXCEPT -
Cerebral venous thrombosis is common
Cerebral venous system is the second most frequent location of thrombosis after hepatic veins.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602837/
Which of the following support a diagnosis of hemolysis?
Decrease in haptoglobin and Low Hb and Hematocrit support a diagnosis of hemolysis
Most common finding in Paroxysmal nocturnal hemoglobinuria is -
Paroxysmal nocturnal hemoglobinuria (PNH) - most common- hemolytic anemia, hemoglobinuria, and shortness of breath.
Other findings - thrombosis, renal insufficiency, and bone marrow failure.
Which is the most common site for thrombosis in PNH patients?
Hepatic vein thrombosis (Budd-Chiari syndrome) is recognized as one of the most common sites of thrombosis
Hepatic failure is a common cause of mortality in PNH
All of the following are correct about Eculizumab EXCEPT -
Meningococcal vaccination is recommended at least 2 weeks before receiving eculizumab
All of the following are useful in treatment of Paroxysmal nocturnal hemoglobinuria as required EXCEPT:
Long-term glucocorticoids not useful and contraindicated
Ankle:Brachial Index
What is Ankle Brachial Index? ABI is a non-invasive tool for the assessment of vascular…
Gait disturbances
Gait disturbancesGaitCause Of GaitCause 1Antalgic Gaitpain2Vaulting gaitcommon in children with limb length discrepancypelvic droop, decreased…
“Cock-walk” gait and “horseshoe moustache” sign
MCQ “Cock-walk” gait and “horseshoe moustache” sign on MRI seen in- A. Hypermagnesemia B. Hypermanganesemia…
